Is glucose-6-phosphate dehydrogenase deficiency a risk factor for melioidosis?

Almurtada Razok¹ , Zohaib Yousaf² , Abdo Lutf³ , Musaed Alsamawi⁴

Keywords: Burkholderia pseudomallei, Glucose-6-phosphate dehydrogenase deficiency, Hemolysis, Melioidosis

DOI: 10.32677/yjm.v1i1.3291

DOI URL: https://doi.org/10.32677/yjm.v1i1.3291

Publish Date: 27-03-2025

Pages: 49 - 51

Views: 5

Downloads: 6

Author Affiliation:

¹Resident,

²Consultant, Department of Medicine, Hamad General Hospital, Doha, Qatar,

³Consultant, Rheumatology Division, 4Consultant, Infectious Diseases Division, Department of Medicine, Alkhor hospital, Qatar

Abstract

Melioidosis is an infection that causes high morbidity and mortality. Predisposing risk factors include diabetes mellitus (DM) and immunocompromised state. We report a case of septic shock secondary to bacteremia caused by Burkholderia pseudomallei in a patient who is supposed to be previously healthy and subsequently diagnosed with DM and glucose-6-phosphate dehydrogenase (G6PD) deficiency. He completed 17 days of intravenous antibiotics followed by a 12-week course of oral trimethoprim/sulfamethoxazole. We postulate that G6PD deficiency could be a risk factor for melioidosis.