Systemic lupus erythematosus manifestation following COVID-19 infection: A coincidental or causal relationship

Muhammed Hajmusa¹ , Raza Ali Akbar^2,3

Keywords: Autoimmunity, Covid-19, Severe acute respiratory syndrome coronavirus 2, Systemic lupus erythematosus

DOI: 10.32677/yjm.v1i1.3271

DOI URL: https://doi.org/10.32677/yjm.v1i1.3271

Publish Date: 27-03-2025

Pages: 46 - 48

Views: 2

Downloads: 6

Author Affiliation:

¹Resident,

² Senior Consultant, Department of Medicine, Hamad General Hospital, Doha, Qatar,

³Assistant Professor, Department of Clinical Medicine, Weill Cornell Medical College, Arryan, Qatar

Abstract

Several intricate interactions of environmental and genetic factors can lead to autoimmune conditions in susceptible hosts. Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease which can be triggered or exacerbated by infection or infectious reactions. The causal link between infections and autoimmunity has been established through clinical studies. Although several viral infections have been associated with SLE, yet the impact of COVID-19 on SLE onset and flares has not been well established. We report a young female who developed new-onset SLE shortly after having COVID-19 infection. Her clinical and lab parameters were highly suggestive of SLE and she responded to standard medical therapy. We also briefly discuss the pathogenetic mechanisms of autoimmunity in cases of viral infections.