yemenjmedYemen Journal of MedicinecoVolume 2 Issue 2 MultidisciplinaryEnglishMay-August 2023NNY20230928ArticleIntravenous dexamethasone-induced perineal pain in childrenEnglishY120121Maher MohamadNajm1EnglishN2EnglishYNermen KhaledAl-Halak3EnglishY10.32677/yjm.v2i2.4260Dexamethasone is one of the most commonly used corticosteroids in pediatric practice, especially for allergies and various types of airway inflammation. Since the 1980s, there have been many reports of the occurrence of short-lived, self-limiting, and unpleasant perineal pain in adults, particularly women, following intravenous administration [1,2]. In this letter, we describe two cases of young girls who suffered from severe anogenital pain that occurred immediately after starting the injection of intravenous dexamethasoneEnglishhttps://www.yemenjmed.com/admin/abstract?id=72References1619Baharav E, Harpaz D, Mittelman M, et al. Dexamethasone-induced perineal irritation.and;nbsp;N Engl J Med. 1986;314(8):515-516.Singh M, Sharma CS, Rautela RS, et al. Intravenous Dexamethasone Causes Perineal Pain and Pruritus. J Anesthe Clinic Res.2011; S1:001.Zhang, Y., Liang, H., Huang, L., et al. The effect of dilution with glucose and prolonged injection time on dexamethasone-induced perineal irritationand;thinsp;and;ndash;and;thinsp;A randomized controlled trial. Open Medicine. 2022;17(1): 1509-1514.Wang J, Li J, Cao H, et al. Intravenous lidocaine suppresses dexamethasone-induced perineal pruritus during anesthesia induction: a randomized controlled, double blind study.and;nbsp;Pak J Pharm Sci. 2015;28(2):569-572.Rewari V, Garg R, Trikha A, et al. Fentanyl pretreatment for alleviation of perineal symptoms following preoperative administration of intravenous dexamethasone sodium phosphate--a prospective, randomized, double blind, placebo-controlled study.and;nbsp;Middle East J Anaesthesiol. 2010;20(6):803-808.