yemenjmedYemen Journal of MedicinecoVolume 3 Issue 3MultidisciplinaryEnglishSeptember- December 2024NNY20241215ArticleHypothermia therapy in neonatal hypoxic-ischemic encephalopathy: Current perspectives, combination therapy and future directionsEnglishY182189Moaaz Abo Zeed1*EnglishNMaher Mohamad Najm2EnglishY3EnglishYArwa Ajaj4EnglishYMohamad Ahmad Ajaj5EnglishY10.18231/j.yjom.2024.019Hypoxic-ischemic encephalopathy (HIE) in neonates, resulting from oxygen deprivation during birth, is a significant cause of death and long-term disabilities. Therapeutic hypothermia has emerged as a pivotal intervention for improving neurological outcomes in infants with HIE. This review aims to summarize current practices, outcomes, and challenges of hypothermia therapy in neonatal HIE, and adjuvant therapies, along with future directions in this evolving field. EnglishTherapeutic hypothermia, Hypoxic­ischemic encephalopathy, Cooling, Neonatal neuroprotectionhttps://www.yemenjmed.com/admin/abstract?id=7References16191.and;nbsp;and;nbsp; and;nbsp;Korf JM, Mccullough LD, Caretti V. A narrative review on treatment strategies for neonatal hypoxic ischemic encephalopathy. Transl Pediatr. 2023;12(8):1552and;ndash;71. 2.and;nbsp;and;nbsp; and;nbsp;Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2013;31(1):CD003311. 3.and;nbsp;and;nbsp; and;nbsp;Acun C, Karnati S, Padiyar S, Puthuraya S, Aly H, Mohamed M. Trends of neonatal hypoxic-ischemic encephalopathy prevalence and associated risk factors in the United States. 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