yemenjmedYemen Journal of MedicinecoVolume 4 Issue 1MultidisciplinaryEnglishJanuary- April 2025NNY20250523ArticleDetermine the Relationship Between Hypertension and Uterine FibroidsEnglishY160163Md Sayed AliSheikh1EnglishNUmmeSalma2EnglishY10.63475/yjm.v4i1.0005Background: Numerous studies have linked uterine fibroids to hypertension, suggesting that this condition may be a risk factor unique to women. These days, fibroids are the main cause of myomectomy and hysterectomy. This study aimed to ascertain the relationship between uterine fibroids and hypertension in Saudi women. Methods: This case-control study was carried out between January 2023 and January 2024 on patients with uterine fibroids and non-uterine fibroids who had an appointment for surgery at the gynecological department of the Maternal and Children Hospital (MCH) Sakaka, Aljouf, Saudi Arabia. Blood pressure readings and fibroid diameters are important factors in studying uterine fibroids. Results: The 140 individuals who were split into 70 cases and 70 control groups had average ages of 41.62±2.16 and 44±1.10. 95 participants had menorrhagia, which was the most common ailment in both groups. In contrast to the controls, the uterine fibroid cases had significantly higher rates of anemia (54.2%), OCP (12.8%), infertility (11.4%), and abortion (37.1%) (PEnglishHypertension, Uterine Fibroid, Factors Relationship, Case-control.https://www.yemenjmed.com/admin/abstract?id=156References1619Haan YC, Diemer FS, Van der Woude L, Van Montfrans GA, Oehlers GP, Brewster LM. The risk of hypertension and cardiovascular disease in women with uterine fibroids. J Clin Hypertens (Greenwich) 2018;20(4):718-26.Becker ER. National trends and determinants of hospitalization costs and lengths-of-stay for uterine fibroids procedures. J Health Care Finance. 2007;33(3):1-16.Fields K, Neinstein L. Uterine myomas in adolescents: case reports and a review of the literature. J Pediatr Adolesc Gynecol. 1996;9(4):195-8.Bulun SE. Uterine fibroids. N Engl J Med. 2013; 369:1344and;ndash;1355.Chen Y, Lin M, Guo P, Xiao J, Huang X, Xu L, et al. Uterine fibroids increase the risk of hypertensive disorders of pregnancy: a prospective cohort study. J Hypertens .2021; 39:1002and;ndash;1008.Chen Y, Xiong N, Xiao J, Huang X, Chen R, Ye S, et al. Association of uterine fibroids with increased blood pressure: a cross-sectional study and meta-analysis. Hypertens Res. 2022; 45:715and;ndash;21.Laughlin SK, Baird DD, Savitz DA, Herring AH, Hartmann KE. Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound-screening study. Obstet Gynecol. 2009; 113:630and;ndash;5.Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol. 2003;188(1):100-7.Vitiello D, McCarthy S. Diagnostic imaging of myomas. Obstet Gynecol Clin North Am. 2006;33(1):85-95.Sabrina Q. Rashid, Yi-Hong Chou, Chui-MeiTiu. Ultrasonography of Uterine Leiomyomas. Journal of Medical Ultrasound. 2016; 24:3-12.Horjus DL, Bokslag A, Hutten BA, van den Born BH, Middeldorp S, Vrijkotte TGM. Creatine kinase is associated with blood pressure during pregnancy. J Hypertens. 2019; 37:1467and;ndash;1474.Ciebiera M, Włodarczyk M, Zgliczyn and;acute;ska M, et al. The role of tumor necrosis factor in the biology of uterine fibroids and the related symptoms. Int J Mol Sci. 2018; 19:3869.Verduijn M, Siegerink B, Jager KJ, Zoccali C, Dekker FW. Mendelian randomization: use of genetics to enable causal inference in observational studies. Nephrol Dial Transplant. 2010 25:1394and;ndash;8.Visscher PM, Brown MA, McCarthy MI, Yang J. Five years of GWAS discovery. Am J Hum Genet. 2012; 90:7and;ndash;24.Orekoya O, Kuye-Kuku T, Fabamwo A, Akinola O, Ayanbode O. Comparative plasma levels of angiotensin II in women with or without uterine fibroid in Lagos state university teaching hospital, Ikeja, Lagos, Nigeria. J Gynecol Res Rev Rep. 2022 (4) 2022; 149:11-3Ziogas A, Papadopoulou A, Kalantzi S, Lamari I, Poulopoulou D, Liasidi P, et al. 321 the correlation between uterine fibroids and hypertension: a bilateral approach. Europ J Obstetr Gynecol Reprod Biol. 2022;270: e92.