yemenjmedYemen Journal of MedicinecoVolume 4 Issue 1MultidisciplinaryEnglishJanuary- April 2025NNY20250522ArticleA Comparative Study of Serum Leptin in Normotensive and Pre-eclamptic Nigerian WomenEnglishY123127OsamudiaOkhionkpamwonyi1EnglishN2EnglishYInnocentOkoacha1EnglishY2EnglishYAimiehinor EAkhator1EnglishY2EnglishYPatrick IOkonta1EnglishY2 EnglishY10.63475/yjm.v4i1.0002Background: Pre-eclampsia remains a significant contributor to maternal and perinatal morbidity and mortality. Research into changes associated with the disease offers some hope into identifying predictive and prognostic factors. In recent times, serum leptin has attracted interest as a possible marker for the disease. The aim of this study was to determine and compare the serum leptin levels in normotensive and pre-eclamptic pregnant women attending antenatal clinic at the Delta State University Teaching Hospital, Oghara, Delta State, Nigeria.  Methods: This was a prospective case-control study design at the Delta State University Teaching Hospital, Oghara, Nigeria in which sixty three pregnant women who received antenatal care and developed pre-eclampsia were recruited into the study. For each selected pre-eclamptic, a matched normotensive was selected as control. Serum leptin level was measured by radio-immunoassay (RIA) ELISA. Results: There was a statistically significant difference in mean serum leptin levels between the normotensive and pre-eclamptic pregnant patients 15.11±4.81 ng/dl vs 38.98±8.66 ng/dl; pEnglishPregnancy, Serum Leptin, Pre-eclampsia, Nigerian Women, DELSUTHhttps://www.yemenjmed.com/admin/abstract?id=150References1619Njelita IA, Nwachukwu CC, Eyisi GI, Akabuike JC, Ezenyeaku CA, Ifeadike CO. Determinants of Preeclampsia in a Tertiary Hospital in South East Nigeria, Intl J Med Sci. 2021; 8(6):5490-5497Uzma Iftikhar A, Mehjabeen AI, Khemomal AK. Evaluation of serum leptin levels during normal pregnancy and preeclampsia. J Ayub Med Coll Abbottabad. 2008;20(4):137-140.Okoye HC, Efobi CC, Ugwu EO, Nwagha TU. ABO Blood Group as a Biomarker of Preeclampsia among Antenatal Clinic Attendees in Nigeria. Niger J Clin Pract. 2020;23(5):729-733.Adeyeye OV, Ebubechukwu NV, Olanrewaju OF, Eniayewun AG, Nwata C, Effiong FB,Unim B. Management and Prevention of Pre-Eclampsiain Nigeria. Healthcare. 2023;11(13): 1832Ekele BA, Airede LR, Legbo JN, Yabubu A Nnadi DC, Gana MA.Spontanous liver rupture in preeclampsia.Afri J Med Sci. 2006;35(1):103-105.Acromite M, Ziotopoulu M, Orlova C, Mantzoros C. Increases leptin levels in preeclampsia: Association with BMI, estrogen and SHBG levels. Hormone. 2010;3(1):46-62.ACOG. Clinical Management Guidelines for Obstetrician and;ndash; Gynecologists. Obstet Gynecol.2019;133(76):168and;ndash;86.Uzan J, Carbonne M, Piconne O, Asmar R, Jean-Marc A. Preeclampsia: pathophysiology, diagnosis and management. Vasc Health Risk Manag.2011;7:467-474.Thapa K, Jha R. Magnesium sulphate: a life saving drug. JNMA J Nepal Med Assoc. 2008;47:104-108.Olaoye T, OyerindeOO,Elebuji OJ, Ologun O. Knowledge, Perception and Management of Pre-eclampsia among Health Care Providers in a Maternity Hospital. Int J MCH AIDS 2019;8(2):80-88.Jerath R, Barnes VA, Fedel HE. Mechanism of development of preeclampsia linking breathing disorder to endothelial dysfunction. Med Hypotheses. 2009;73(2):163-166.Martinez-Sanchaz N, There and Back Again: Leptin Actions in the White Adipose Tissue.and;nbsp; Int J Mol Sci, 2020;21(17):6039.Tal R. The role of hypoxia and hypoxic inducible factor-1 alpha in preeclampsia pathogenesis. BiolReprod. 2012;87(6):134-139.Szpera-Gozdziewicz A, Breborowicz GH. Endothelial dysfunction in the pathogenesis of preeclampsia. Front Bio Sci.2014;19:734-746.Myatt L, Clifton RG, Robert JM, Spong CY,and;nbsp; Hauth JC, Varner MW et al. First trimester prediction of preeclampsia in nulliparapous women at low risk. Obstet Gynecol. 2012;119(6):1234-1242.Ghojazaeh M, Amami-Aghdash S, Mohammadi M, Vosoogh S. Prognosis and risk factor for early diagnosing of preeclampsia in nullipara. Niger Med J.2013;54(5):344-348.Charan J, Biswas T. How to calculate sample size for different study designs in medical research. Indian J Psychol Med. 2013;35:121-126.De-Knegt VE, Hedley PL, Kanters JK, Thagaard IN, Krebs L, Christiansen M, Lausten-Thomas U.Theand;nbsp; Role of Leptin in Fetal Growth during Pre-Eclampsia. Int J Mol Sci. 2021;22(9): 4569. doi/10. 3390/ijms22094569Mol Hum Reprod. 2006; 12:551-556.Firdous M, Abdul RM, Sajida Y, Tahir SM. Role of serum leptin level as a marker of severity of preeclampsia. J Ayub Med Coll Abbottabad. 2008;20(1):13-15.Shahat EL, Mohamed A, Ahmed AB, Mohamed HS, Ahmed MR . Maternal serum leptin as a marker of preeclampsia. Arch Gynecol Obstet.2013;288(6):1317-1321.Zeng S, Liu Y, Fan P, Yang L, Liu X. Role of leptin in the pathophysiology of preeclampsia.and;nbsp; Placenta. 2023;142:128-134.De Arruda Veiga EC, Korkes HA, Salomao KB, Cavalli RC. Association of Leptin and other inflammatory markers with pre-eclampsia: A systematic review. Front Pharmacol2022;13:96600.Min-Jung P, Dong-Hyung L, Bo-Sun J, Young-Joo L, Jong-Kil J,Beum-Soo A, Seung-Chul K, Kyu-Sup L. Leptin, leptin receptorsand;nbsp; and hypoxia-induced factor-1a expression in the placental bedof patients with and without preeclampsiaduring pregnancy. Mol Med Reports 2018; 5292-5299.Wang S, Qlao FY, Feng I. High leptin level and leptin receptor Lys656Asn variant are risk factors for preeclampsia. Genet Mol Res.2013;12(3):2416-2422.Sucak A, Kanat-Pektas M, Gungor T, Mollamahmutoglu L. Leptin levels and antihypertensive treatment in preeclampsia. Singapore Med J. 2010,51(1):30-43.Asnafi N, Sharbatdaran M, Hajian K.Comparism of maternal and neonatal serum leptin levels in preeclampsia and normal pregnancy. Iran J Reprod Med.2011; 9(2):131-134.Thomas L, Ashworth CJ, Hoggard N, Mercer JG, Wallace JM, Lea RG. Decreased maternal serum leptin in pregnancies complicated by preeclampsia. Reprod Sci. 2001;8(2):89-92.Martinez-Abundis E, Gonzalez-Ortiz M, Pascoe-Gonzalez S. Serum leptin levels severity of pre-eclampsia. Arch Gynae Obstet. 2000;264(2):71-73.Salimi S, Farajian-Mashhadi F, Naghavi A, Mokhtari M, Shahrakipour M, Saravani M, et al. Different profile of serum leptin between early onset and late onset preeclampsia. Dis Markers. 2014;2014:628476.Rivera MY, Ning Y, Fredrec N. Leptin, Soluble leptin receptor and leptin gene polymorphism in relation to pre-eclampsia risk. Physiol Res. 2005; 54: 167-74.Bakrania BA, Spradley FT, Drummond HA, LaMarca B, Ryan MJ, Granger JP. Preeclampsia: Linking Placental Ischaemia with Maternal Endothelial and Vascular Dysfunction. ComprPhysiol 2020; 11(1):1315-1349Masuyama H, Segawa T, Sumida Y. Different profile of circulating angiogenic factors and adipocytokines between early and late-onset pre-eclampsia. BJOG. 2010;117(3):314-320.Agbogu-Ike OU, Ogoina D, Onyemelukweand;nbsp; GC. Leptin Concentrations in Non and;ndash;Obese and Obese Non-Diabetes Nigerian Africans. Diabetes Metab Syndr Obes. 2021;21(14):4889-4902.